To support clinical trial designs focused on early interventions, a new study aimed to characterise early Aβ accumulation based on Centiloids (CL) in a pre-dementia population, by (1) estimating the variability of longitudinal CL measurements in a population expected to remain stable over time in order to define reliable accumulation beyond measurement error, (2) establishing the baseline CL threshold that optimally predicts future accumulation, and (3) describing the rates of Aβ accumulation across the whole population and investigating their relation to visual read status over time. Findings were published in the journal Alzheimer’s & Dementia.

This work used clinical and imaging data from the AMYPAD Prognostic and Natural History Study (PNHS), downloaded from the Alzheimer’s disease data initiative (ADD) workbench.

Congratulations to all authors: Ariane Bollack, Lyduine E. Collij, David Vállez García, Mahnaz Shekari, Daniele Altomare, Pierre Payoux, Bruno Dubois, Oriol Grau-Rivera, Mercè Boada, Marta Marquié, Agneta Nordberg, Zuzana Walker, Philip Scheltens, Michael Schöll, Robin Wolz, Jonathan M. Schott, Rossella Gismondi, Andrew Stephens, Christopher Buckley, Giovanni B. Frisoni, Bernard Hanseeuw, Pieter Jelle Visser, Rik Vandenberghe, Alexander Drzezga, Maqsood Yaqub, Ronald Boellaard, Juan Domingo Gispert, Pawel Markiewicz, David M. Cash, Gill Farrar, Frederik Barkhof

You can access the paper here: https://doi.org/10.1002/alz.13761