A new paper titled “Implementing robust amyloid PET quantification in multi-center studies: AMYPAD approach to address data acquisition, processing, interpretation and data sharing challenges” has been published in Alzheimer’s & Dementia: Translational Research & Clinical Interventions. In this work, wer present the amyloid-PET standards for quantification implemented across the two AMYPAD trials, relying on extensive amyloid-PET harmonization efforts across 17 sites and cross-validation of three Centiloid pipelines, providing a practical approach for other multi-center cohorts to implement similar strategies.
Highlights:
- We share AMYPAD’s end-to-end approach to amyloid positron emission tomography (PET) quantification from data acquisition and handling, harmonization based on Hoffman phantoms, quality control, image processing, to data storage, and data sharing strategies.
- Centiloid quantification was compared across one PET-only (AmyPype) and two PET-MR pipelines (standard Centiloid and IXIXO-LEAP). Excellent agreement in dichotomized Centiloid valued was observed both between pipelines and when compared to visual reads.
- Distribution of Centiloid values in the Prognostic and Natural History Study (PNHS) and Diagnostic and Patient Management Study (DPMS) are in line with the initial recruitment strategies of the trials.
- Harmonization of Amyloid-PET scans framework was adopted by EARL as the Brain PET/CT accreditation standard for multicentre brain PET scans.
You can download the paper here: https://doi.org/10.1002/trc2.70190
Congratulations to all authors: Ariane Bollack, Mahnaz Shekari, Lyduine E. Collij, Emma Luckett, David Valléz García, Pawel Markiewicz, Robin Wolz, Maqsood Yaqub, Alle Meije Wink, Rossella Gismondi, Andrew Stephens, Pieter Jelle Visser, Anja Mett, Alexander Drzezga, Christopher Buckley, Juan Domingo Gispert, Gill Farrar, Frederik Barkhof
