A new paper entitled “Decreased amyloid-related structure–function coupling in preclinical Alzheimer’s disease” has been published in the journal Communications Medicine. In this study, authors examined how Amyloid-β affects the relationship between brain structure and brain activity in older adults without dementia. For this, they analysed brain scans from 460 participants from the AMYPAD Prognostic and Natural History Study (PNHS).

You can download the paper here: https://doi.org/10.1038/s43856-026-01707-2

Congratulations to all authors: Prithvi Arunachalam, Leonard Pieperhoff, Luigi Lorenzini, Mario Tranfa, Federico Masserini, Francesca Treves, Giuseppe Pontillo, Maria G. Preti, Tommy A. A. Broeders, Menno M. Schoonheim, Linda Douw, Craig Ritchie, Mercè Boada, Marta Marquié, Pieter Jelle Visser, Raffaele Cacciaglia, Juan Domingo Gispert, Gemma Salvadó, Emma S. Luckett, Lyduine E. Collij, James H. Cole, Frederik Barkhof & Alle Meije Wink On behalf of the AMYPAD consortium