AMYPAD features prominently at AAIC2022

The 2022 Alzheimer’s Association International Conference (AAIC) took place from 31^st July to 4^th August as a hybrid event (online and in San Diego, US). This year, the conference attracted over 10,000 attendees and included more than 4,000 scientific presentations. Please visit the AAIC 2022 website to learn more about the research findings and discoveries that were shared by researchers from around the globe.

We were pleased that AMYPAD had the opportunity to hold a Featured Research Session. The session entitled ‘“Progressing the clinical and technical value of amyloid PET in dementia – the AMYPAD experience” was chaired by Lyduine Collij and Hugh Pemberton, and consisted of four oral presentations:

“Steps towards the implementation of amyloid-PET in memory clinics: AMYPAD Diagnostic and Patient Management Study” Daniele Altomare
“Evaluating the sensitivity of Centiloid quantification to pipeline design and image resoloution” Mahnaz Shekari
“Quantitative amyloid-PET measures in a memory clinic population” Lyduine Collij
“First results of the AMYPAD Prognostic and Natural History Study: amyloid-PET centiloids predicts cognitive functioning in a pre-dementia population” David Vállez García

In addition to the Featured Research Session, the AMYPAD team presented twelve posters on different aspects of the project. If you have missed the event, do not hesitate to download the AMYPAD posters on our website here.

“Quantifying AD-related brain amyloid with linearised progression models: model-based vs. data-based” Alle Meije Wink
“Predictive value of a plasma p-tau181-specific assay for amyloid accumulation in asymptomatic Alzheimer’s Disease” Steffi De Meyer
“Validation of a continuous model of amyloid-β CSF/PET discordance across cohorts and PET tracers” Elena Rodriguez-Vieitez
“The use of amyloid-PET in memory clinic patients: AMYPAD Diagnostic and Patient Management Study” Daniele Altomare
“Impact of reduced injected dose on quantification of in vivo amyloid-β pathology using [18F]flutemetamol” Peter Young
“Evaluating the sensitivity of Centiloid quantification to pipeline design and image resolution” Mahnaz Shekari
“Increased cerebral blood flow is associated with higher baseline amyloid burden in a cognitively unimpaired population” Beatriz Padrela
“Inverse relationship between education and amyloid burden in individuals with subjective cognitive decline plus and mild cognitive impairment” Merle Hönig
“First results of the AMYPAD Prognostic and Natural History Study: amyloid-PET Centiloid predicts cognitive functioning in a pre-dementia population” David Vállez García
“Towards a Data-Driven Reference Region Approach for [F18]AV45 Amyloid PET: Evaluation of Longitudinal Sensitivity and Tracer-Specificity of New and Common Reference Regions” Julia Pfeil
“Differences in dynamic functional connectivity across the Alzheimer’s disease spectrum” Julia Pfeil
“Spatial-temporal subtypes of amyloid deposition show distinct baseline and longitudinal cognitive profiles”, Sophie E. Mastenbroek

If you were registered for AAIC and missed the above presentations, please note that all of these presentations are available on the conference platform until 1 September.

We would like to congratulate Agneta Nordberg who received the Henry Wisniewski Lifetime Achievement Award. This award honors significant contributions to Alzheimer’s and dementia research, either through a single scientific discovery or a body of work. Agneta Nordberg is a professor of clinical neuroscience and director of the Nordberg Translational Molecular Imaging Lab at the Karolinska Institutet (KI), as well as a senior consultant in geriatric medicine at Karolinska University Hospital. She is also the Principal Investigator for the AMYPAD study in Stockholm. Her research currently focuses on developing early diagnostic biomarkers and new drug targets in Alzheimer’s disease and other neurodegenerative disorders. She has contributed greatly to the field’s understanding of the neurotransmitter acetylcholine’s role in dementia, and has pioneered the use of brain amyloid positron emission tomography (PET) imaging as well as PET imaging to visualize abnormalities in tau protein and reactive astrogliosis.

Save the date for the next Alzheimer’s Association International Conference to be held on 16-23 July 2023 in Amsterdam (Netherlands).

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