A new paper titled “Cortical gray–white matter contrast alterations precede amyloid-β positivity and macrostructural changes in older adults without dementia” has been published in the journal Alzheimer’s & Dementia. In this work, authors analysed cross-sectional MRI and amyloid-β (Aβ) positron emission tomography (PET) data from 1323 AMYPAD participants.
Highlights:
- Cortical micro- and macro-structural magnetic resonance imaging (MRI) measures capture distinct processes
- Amyloid burden relates most strongly to gray–white matter contrast loss
- Microstructural MRI alterations emerge before cortical atrophy
- Gray–white matter contrast changes precede amyloid-β positivity by several years
You can download the paper here: https://doi.org/10.1002/alz.71609
Congratulations to all authors:Leonard Pieperhoff, Luigi Lorenzini, Francisco Almeida, Mario Tranfa, Ariane Bollack, Prithvi Arunachalam, Federico Masserini, Robin Wolz, Sylke Grootoonk, Craig Ritchie, Mercè Boada, Marta Marquié, Jort Vijverberg, Rik Vandenberghe, Bernard J. Hanseeuw, Pablo Martinez-Lage, Pierre Payoux, Pieter Jelle Visser, Michael Schöll, Giovanni B. Frisoni, Matteo Pardini, Luca Roccataglia, Andrew W. Stephens, Chris Buckley, Gill Farrar, Frank Jessen, Juan Domingo Gispert, Gemma Salvadó, Emma S. Luckett, Henk-Jan MM Mutsaerts, Alle Meije Wink, Lyduine E. Collij, Frederik Barkhof, Tiago Gil Oliveira, the AMYPAD consortium
