A new AMYPAD review entitled “Longitudinal amyloid and tau PET imaging in Alzheimer’s disease: A systematic review of methodologies and factors affecting quantification” has been published in the journal Alzheimer’s & Dementia. In this review, authors reviewed the literature using traditional sources and meeting abstracts and presentations. The review focuses on dementia-related research studies involving longitudinal positron emission tomography (PET), and recent developments in scan acquisition, data processing, and analysis. The findings provide an overview of the current methodologies used in longitudinal PET studies. Sources of variability affecting the measure of change in amyloid and tau deposition are described, including how to address them, and which methodological features should be reported.
Congratulations to all authors, Ariane Bollack, Hugh G. Pemberton, Lyduine E. Collij, Pawel Markiewicz, David M. Cash, Gill Farrar and Frederik Barkhof!
You can read the paper here: https://doi.org/10.1002/alz.13158