New paper out determining reliable amyloid accumulation in Centiloids

To support clinical trial designs focused on early interventions, a new study aimed to characterise early Aβ accumulation based on Centiloids (CL) in a pre-dementia population, by (1) estimating the variability of longitudinal CL measurements in a population expected to remain stable over time in order to define reliable accumulation beyond measurement error, (2) establishing the baseline CL threshold that optimally predicts future accumulation, and (3) describing the rates of Aβ accumulation across the whole population and investigating their relation to visual read status over time. Findings were published in the journal Alzheimer’s & Dementia.

This work used clinical and imaging data from the AMYPAD Prognostic and Natural History Study (PNHS), downloaded from the Alzheimer’s disease data initiative (ADD) workbench.

Congratulations to all authors: Ariane BollackLyduine E. CollijDavid Vállez GarcíaMahnaz ShekariDaniele AltomarePierre PayouxBruno DuboisOriol Grau-RiveraMercè BoadaMarta MarquiéAgneta NordbergZuzana WalkerPhilip ScheltensMichael SchöllRobin WolzJonathan M. SchottRossella GismondiAndrew StephensChristopher BuckleyGiovanni B. FrisoniBernard HanseeuwPieter Jelle VisserRik VandenbergheAlexander DrzezgaMaqsood YaqubRonald BoellaardJuan Domingo GispertPawel MarkiewiczDavid M. CashGill FarrarFrederik Barkhof

You can access the paper here:

New paper out determining reliable amyloid accumulation in Centiloids
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