A new paper titled “Self-reported sleep quality and longitudinal amyloid burden in clinically unimpaired adults from the AMYPAD PNHS study” has been published in Alzheimer’s Research & Therapy. In this work, authors investigated associations between self-reported sleep quality and Aβ burden longitudinally in clinically unimpaired (CU) adults from the AMYPAD PNHS cohort. 

This study found that poor subjective sleep quality is associated with an increased amyloid burden over time only when individuals show intermediate Aβ deposition levels at baseline (between 12 and 50 CL). These findings identify a critical therapeutic window that could optimize patient selection and enhance the efficacy of sleep-targeted interventions in future clinical trials.

You can download the paper here: https://doi.org/10.1186/s13195-026-02049-w

Congratulations to all authors: Núria Tort-Colet, Laura Stankeviciute, Ana Fernández-Arcos, Natalia Soldevila-Domenech, Gonzalo Sánchez-Benavides, Mahnaz Shekari, David Vállez García, Daniele Altomare, Frederik Barkhof, Mercè Boada, Christopher Buckley, Lyduine E. Collij, Anouk den Braber, Gill Farrar, Lisa Ford, Giovanni B. Frisoni, Rossella Gismondi, Juan D. Gispert, Sylke Grootoonk, Bernard J. Hanseeuw, Frank Jessen, Emma S. Luckett, Richard Manber, Marta Marquié, the AMYPAD Consortium