The AMYPAD Prognostic and Natural History Study (PNHS) has completed its inclusion of participants with a broad range of biomarkers, including (advanced) MR and amyloid-PET imaging, neuropsychological and neuropsychiatric assessments, cerebrospinal fluid, genetics, and functional performance. This study was initiated and sponsored by the VUmc Amsterdam and involves 17 sites in over 10 countries across Europe. The wealth of available data requires a dedicated PhD student to further our understanding of the earliest brain changes associated with Alzheimer’s disease.
The PhD candidate will work with the available multimodal and multicenter MRI dataset of the pan-European consortium. During the course of the PhD, you will contribute to the creation of standardized pipelines for the processing, quality control, and harmonization of this diverse dataset, which includes structural (T1w, T2w, FLAIR, SWI), functional (fMRI and ASL) and diffusion (DTI) sequences. A particular focus of your research will be on using multivariate analysis to investigate the single- and multi-modal MRI phenotypes, their interaction with risk factors, and association with AD disease progression. This project is a continuation of previous and ongoing works with a focus on multimodal brain network alterations, assessed through these different modalities.
For more information about the job position and how to apply, please visit here.