Hope this newsletter finds you well in these slightly improving times and that everyone is able to stay healthy. With the vaccination rates improving throughout Europe, I hope we can say that we are almost there! Over the past few months I have seen great motivation throughout the AMYPAD team, aiming to catch up the backlog that was created in the past year. I would like to thank the whole consortium for their commitment and effort in bringing AMYPAD to a successful end!

Within that context, the official no-cost extension approval by IMI will allow us to continue our endeavours until September 2022. In this way, I am confident we can complete the delivery of the work plan. With the data of the Diagnostic and Patient Management Study (DPMS) undergoing rigorous quality controls and the data of the  Prognostic and Natural History Study (PNHS), every growing, I expect an exciting final year for AMYPAD.

This week, a huge milestone was reached for the PNHS, with the recruitment of our 1,000^th prospective participant! Also, two additional Parent Cohorts have joined our collaborative framework; the Microbiota cohort from Geneva and the EMIF-AD 90+ cohort from Amsterdam. Through our collaborations, we currently have over 1,200 subjects and 1,800 PET scans collected within the PNHS. With the approvals of protocol version 5.0 coming in, we will be able to continue recruitment and follow-up for one additional year. Finally, to integrate data from the various Parent Cohorts, the WP4 team has been working intensively with the Aridhia team to harmonize and pool all available data.

Also, a lot of work in the harmonization of the PET scans has been performed by our WP2 team, and in particular the BBRC team in collaboration with IXICO. This a major task, which will ensure the data quality of our primary imaging data.

Finally, several abstracts have been accepted for either a poster or oral presentation at this year’s AAIC conference. I am pleased to see that the project will be broadly represented!

Stay well and remain connected!

This electronic newsletter will be published quarterly and be accessible via the AMYPAD website (www.amypad.eu). In this issue, we present you the achievements of the past quarter and the latest AMYPAD papers. In addition, you can also get to know two AMYPAD collaborators, Merle Hönig and David Vállez García who share some of their expectations with us.

You can download the newsletter here.