Risk stratification: natural history and enrichment strategies

This work stream in AMYPAD is ultimately tasked with ensuring efficiencies in delivering the interaction with the EPAD Programme and other deep phenotyped European cohorts of cognitively unimpaired participants (ECCU). PET-Amyloid imaging up to 2000 subjects enrolled in the EPAD LCS or other non EPAD cohorts are undertaken. A sub-population of these subjects will have a repeat PET Amyloid scan conducted 1-2 years later. The PET-Amyloid imaging represents an additional important biomarker amongst a multitude of cognitive, imaging and CSF biomarkers already performed in the EPAD LCS and in the remaining ECCUs.

Objective:
To focus on understanding natural history of AD, defining the window for intervention and trial-readiness population in conjunction with EPAD Longitudinal Cohort Study and other similar European Cohorts.