The 2020 Alzheimer’s Association International Conference (AAIC) took place from 26-30 July and for the first time was held as an entirely virtual conference.

More than 32,000 registered attendees from over 160 countries joined the meeting online to discuss the latest studies, theories and discoveries that will help bring the world closer to breakthroughs in dementia science. Please visit the AAIC 2020 website to learn more about the research findings and discoveries that were shared by researchers from around the globe.

We were pleased that AMYPAD had the opportunity to hold a Featured Research Session. The session entitled ‘“The value of amyloid PET beyond dichotomization” was chaired by Isadora Lopes Alves and Christopher Buckley, and consisted of four oral presentations:

• Isadora Lopes Alves “A multi-study analysis of the spatial-temporal progression of amyloid deposition and its utility for longitudinal studies” (Download the slides here).
• Lyduine Collij “Examining Centiloid quantification against visual assessment using [18F]flutemetamol PET” (Download the slides here).
• Santiago Bullich “Converging evidence for a “gray-zone” of amyloid burden and its relevance”
• José Luis Molinuevo “Emerging beta-amyloid pathology is associated with tau, synaptic, neurodegeneration and gray matter volume differences” (Download the slides here).

We organised a live Q&A where delegates had the opportunity to interact with our chairs and speakers. This session generated a great deal of interest and an active participation from the attendees.

In addition to the Featured Research Session, the AMYPAD team made additional presentations at the conference on different aspects of the project:

• Daniele Altomare “AMYPAD DPMS preliminary results: participants’ baseline features” (poster)
• Lyduine Collij “White matter integrity disruption in early amyloid accumulators” (poster)
• Merle Hönig “Resistance to Tau and Amyloid Pathology Supports Super-Aging” (poster)
• Isadora Lopes Alves “Dynamic PET imaging reduces sample sizes to detect longitudinal amyloid accumulation” & “Current Status and Quantitative Results of the AMYPAD Prognostic and Natural History Study” (posters)
• Lea Poitrine “Impact of the disclosure of amyloid-PET results to patients with subjective cognitive decline: the AMYPAD Diagnostic and Patient Management Study (DPMS)” (poster)
• Leon Aksman “Tau-first subtype of Alzheimer’s disease progression consistently identified through PET and CSF” (oral)
• Arianna Sala “Discordant results in CSF/PET Aβ biomarkers are dependent on APOE genotype and related to inter-individual differences in CSF Aβ42, Aβ40 and Aβ38 isoforms” (oral).

If you were registered for AAIC and missed the above presentations, please note that all of these presentations are available on-demand for 1 month for non-members (30th August) and 2-months for ISTAART members (29th September). If you have missed the event, do not hesitate to download the AMYPAD posters on our website here.